A Beginner’s Guide To Cannabinoid Bioavailability

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Both tetrahydrocannabinol and CBD benefits are well documented, but you could easily treat these cannabinoids’ bioavailability as if it is unimportant. The term ‘bioavailability’ refers to the portion of any particular substance that gets into the flowing blood. Consumption methods and physiological processes can affect the absorption of cannabis sativa derivatives. The more bioavailable your cannabis-sativa plant-derived product, lesser will be the amount of it you will have to consume.

Cannabidiol and tetrahydrocannabinol can be ingested as oil-based edibles. A grownup person’s body is 60% water, so we see absorption resistance to tetrahydrocannabinol and cannabidiol oil products. Water and oil cannot form a homogenous mixture. Likewise, cannabis oil cannot mix homogeneously with water because it should go through watery cellular environments.

The Distinction Between CBD’s And THC’s Bioavailability

Research has revealed that both phytocannabinoids’ bioavailability depends on the way you use these. There can be a tenfold increase in cannabidiol’s penetration than tetrahydrocannabinol’s when it is used topically. On the other hand, tetrahydrocannabinol is much more bioavailable as compared to cannabidiol when consumed orally or inhaled. In a recent study, tetrahydrocannabinol’s concentrations in the circulating blood were shown to be 30 to 50% greater than cannabidiol’s when taken sublingually with a spray. However, even when consumed orally, THC has limited bioavailability.

How To Make These Cannabinoids As Bioavailable As Possible

Soft gels, edibles, and tinctures are among the most convenient and common forms of cannabinoid products, but these limit the substances’ bioavailability.

As per Dr. Patricia Frye, an expert in medical cannabis, there is a very variable absorption when these are used in edible form. When used thus, she noted down the following effects.

  • Just 6% of either cannabinoid was absorbed;
  • The substances’ onset could take a maximum of six hours; and,
  • Their effects could last up to twenty hours.

With oral consumption, you will not have to administer a dose often. Thus, the substance will last longer than when it is inhaled, without the possibility of malignancy or irritating the airways as in the case of inhalation. Inhaling either cannabinoid will make it more bio-available as it will then be transported as vapor particles through small air sacs of the lungs. As a result, the cannabinoid gets into the bloodstream quickly by bypassing the liver.

Ways To Increase Cannabinoid Bioavailability

Adding an edible cannabinoid in fats could help in causing it to be absorbed faster. Frye suggests using healthy fats like dark chocolate, hummus, or guacamole with tinctures or edibles.

Taking more puffs of cannabinoid can make it more bio-available. Moreover, Frye recommends dosing cannabinoids on an as-needed basis to achieve this result.